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Kohzoh Imai Selected Research

Matrix Metalloproteinase 7 (Matrilysin)

8/2009Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of matrilysin.
12/2004Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis.
3/2004Expression of ets-related transcriptional factor E1AF is associated with tumor progression and over-expression of matrilysin in human gastric cancer.
8/2003Association of ets-related transcriptional factor E1AF expression with tumour progression and overexpression of MMP-1 and matrilysin in human colorectal cancer.
2/2003Association of trypsin expression with tumour progression and matrilysin expression in human colorectal cancer.
1/2003The expression of matrix metalloproteinase matrilysin indicates the degree of inflammation in ulcerative colitis.

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Kohzoh Imai Research Topics

Disease

143Neoplasms (Cancer)
01/2024 - 01/2002
38Colorectal Neoplasms (Colorectal Cancer)
03/2016 - 01/2002
29Carcinoma (Carcinomatosis)
04/2014 - 01/2002
24Stomach Neoplasms (Stomach Cancer)
07/2014 - 01/2002
17Carcinogenesis
01/2016 - 01/2003
15Neoplasm Metastasis (Metastasis)
01/2024 - 01/2003
15Gastrointestinal Neoplasms (Gastrointestinal Cancer)
01/2017 - 01/2002
14Pancreatic Neoplasms (Pancreatic Cancer)
08/2019 - 01/2003
13Adenoma (Adenomas)
01/2016 - 06/2002
12Adenocarcinoma
08/2019 - 01/2003
11Immunoglobulin G4-Related Disease
01/2016 - 01/2010
11Mikulicz' Disease
11/2014 - 04/2005
10Colonic Neoplasms (Colon Cancer)
03/2013 - 02/2003
9Rheumatoid Arthritis
06/2012 - 04/2003
8Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
04/2014 - 08/2006
7Microsatellite Instability
01/2019 - 08/2002
7Autoimmune Pancreatitis
01/2015 - 04/2005
7Colitis
04/2014 - 06/2003
6Breast Neoplasms (Breast Cancer)
01/2022 - 08/2004
5Esophageal Squamous Cell Carcinoma
02/2014 - 05/2007
5Fibrosis (Cirrhosis)
04/2013 - 07/2010
5Liver Neoplasms (Liver Cancer)
05/2011 - 03/2004
5Multiple Myeloma
03/2011 - 01/2002
4Malignant Mesothelioma
01/2024 - 01/2017
4Hepatocellular Carcinoma (Hepatoma)
08/2011 - 06/2008
4Ulcerative Colitis
06/2009 - 01/2003
3Hereditary Nonpolyposis Colorectal Neoplasms (Hereditary Nonpolyposis Colorectal Cancer)
01/2019 - 04/2008
3Inflammation (Inflammations)
01/2016 - 01/2003
3Hypergammaglobulinemia (Hyperimmunoglobulinemia)
01/2016 - 10/2005
3Tuberculosis (Tuberculoses)
01/2016 - 10/2007
3Dacryocystitis (Dacryoadenitis)
11/2014 - 01/2012
3Sialadenitis
11/2014 - 01/2012
3Hematologic Neoplasms (Hematological Malignancy)
12/2012 - 03/2002
3Systemic Scleroderma (Systemic Sclerosis)
06/2012 - 06/2004
3Biliary Tract Neoplasms (Biliary Tract Cancer)
02/2012 - 09/2005
3Hemorrhage
11/2008 - 03/2002

Drug/Important Bio-Agent (IBA)

24Proteins (Proteins, Gene)FDA Link
01/2024 - 01/2003
20Messenger RNA (mRNA)IBA
03/2013 - 10/2002
18Monoclonal AntibodiesIBA
01/2024 - 03/2002
18DNA (Deoxyribonucleic Acid)IBA
04/2014 - 03/2002
17Immunoglobulin G (IgG)IBA
01/2016 - 01/2002
15MicroRNAs (MicroRNA)IBA
09/2022 - 04/2008
15Small Interfering RNA (siRNA)IBA
01/2022 - 07/2005
14Calcibiotic Root Canal SealerIBA
01/2016 - 10/2004
14DecitabineFDA Link
03/2013 - 12/2003
13Biomarkers (Surrogate Marker)IBA
01/2016 - 02/2004
11MucinsIBA
01/2018 - 01/2002
11MethyltransferasesIBA
03/2016 - 12/2003
11IGF Type 1 Receptor (IGF 1 Receptor)IBA
02/2014 - 10/2003
10Insulin-Like PeptidesIBA
03/2013 - 10/2003
9beta CateninIBA
11/2009 - 04/2005
9Matrix Metalloproteinases (MMPs)IBA
08/2009 - 01/2003
9Complementary DNA (cDNA)IBA
06/2007 - 11/2002
8hydrogen sulfite (bisulfite)IBA
10/2015 - 12/2003
8Histones (Histone)IBA
03/2013 - 01/2002
7Peptides (Polypeptides)IBA
01/2023 - 08/2005
7Transcription Factors (Transcription Factor)IBA
10/2018 - 01/2002
7Histone Deacetylase InhibitorsIBA
06/2011 - 12/2003
6Therapeutic UsesIBA
09/2022 - 09/2004
6LigandsIBA
08/2019 - 03/2002
6Immunoglobulins (Immunoglobulin)IBA
01/2016 - 01/2006
6Adrenal Cortex Hormones (Corticosteroids)IBA
01/2013 - 06/2004
6Indicators and Reagents (Reagents)IBA
12/2012 - 03/2002
6Matrix Metalloproteinase 7 (Matrilysin)IBA
08/2009 - 01/2003
5AntigensIBA
01/2024 - 02/2002
5AntibodiesIBA
01/2018 - 01/2003
5ErbB Receptors (EGF Receptor)IBA
01/2017 - 03/2002
5GlucocorticoidsIBA
01/2015 - 10/2005
5Interferon-gamma (Interferon, gamma)IBA
01/2013 - 03/2004
5Bortezomib (Velcade)FDA Link
11/2012 - 06/2004
5Phosphotransferases (Kinase)IBA
06/2009 - 06/2005
5EnzymesIBA
07/2008 - 11/2002
5romidepsin (FK228)FDA Link
04/2008 - 06/2004
5Cyclooxygenase 2 (Cyclooxygenase-2)IBA
08/2007 - 01/2002
5Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2007 - 03/2003
4SteroidsIBA
01/2015 - 02/2004
4ParaffinIBA
08/2014 - 01/2003
4Formaldehyde (Formol)FDA Link
08/2014 - 01/2003
4AcidsIBA
02/2014 - 06/2004
4Insulin-Like Growth Factor II (Somatomedin A)IBA
02/2012 - 12/2004
4Interleukin-2 (IL2)IBA
10/2011 - 03/2002
4InterferonsIBA
05/2011 - 06/2009
4RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
09/2006 - 08/2003
3OligonucleotidesIBA
09/2022 - 10/2002
3Insulin (Novolin)FDA Link
01/2017 - 01/2002
3ChromatinIBA
01/2016 - 08/2007
3Long Noncoding RNAIBA
01/2016 - 03/2012
3Type 1 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 1)IBA
01/2015 - 10/2008
3Antineoplastic Agents (Antineoplastics)IBA
04/2014 - 03/2003
3Dextran SulfateIBA
04/2014 - 02/2011
3Proteasome InhibitorsIBA
11/2012 - 06/2004
3AutoantibodiesIBA
08/2012 - 02/2006
3Insulin-Like Growth Factor I (IGF-1)IBA
02/2012 - 10/2003
3Bispecific AntibodiesIBA
10/2011 - 03/2002
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
07/2011 - 08/2004
3Dexamethasone (Maxidex)FDA LinkGeneric
03/2011 - 04/2005

Therapy/Procedure

63Therapeutics
01/2024 - 03/2002
15Drug Therapy (Chemotherapy)
01/2019 - 04/2003
8Immunotherapy
01/2024 - 03/2002
4Aftercare (After-Treatment)
04/2013 - 12/2003